regenHU CEO: Bioprinting Will Strengthen OrganTrans Project to 3D Print Liver Organoid

The European consortium OrganTrans is preparing to develop a tissue engineering platform capable of generating liver tissue. The proposed automated and standardized disruptive alternative solution to organ donation for patients with liver disease will stand on 3D bioprinting know-how from Swiss biomedical firm regenHU. Coordinated by Swiss research and development center CSEM, the eight partners and two transplantation centers engaged in the consortium will be using regenHU’s 3D bioprinters to produce organoid-based liver constructs with organoid laden bioinks.

In April 2020, we reported that OrganTrans would tackle the important healthcare challenge of end-stage liver disease (ESLD) by capitalizing on advancements in the regenerative medicine field, like using biofabricated liver tissue, to develop an entire value chain from the cell source to tissue engineering, biofabrication, post-processing and testing, and liver transplantation under the “compassionate use exemption” regulation (which provides an important pathway for patients with life-threatening conditions to gain access to unproven human cells and tissue products). To understand the key role of biofabrication in this innovative project, 3DPrint.com asked regenHU’s new CEO, Simon MacKenzie, to tell us more about the challenges that lie ahead for the European consortium and his company.

regenHU CEO Simon MacKenzie (Image courtesy of regenHU)

The project officially began in January 2020, what can we expect when it ends in December 2022?

The current goal of this project is to create a functional biofabricated liver construct that can be implanted into a mouse model. I consider that the OrganTrans team will accelerate new solutions for patients with liver failure. It is challenging, but we do envision successful in vivo trials. Of course, this major achievement will not be the end of the story; significant work and research will still be required to transfer these results to human clinical trials. The major remaining challenges will probably be the process scale-up to produce larger tissue and regulatory aspects.

Will this research be groundbreaking to treat liver disease in the future?

Demonstrating the feasibility of the approach in a mouse model will be groundbreaking for the disease because it will demonstrate its potential as an alternative to transplantation. Diseases like NASH [nonalcoholic steatohepatitis, an aggressive form of fatty liver disease] are increasing dramatically, and likely to be a leading cause of death within the next few years. Moreover, the difficulty of detecting the disease until it is potentially too late leads to significant challenges for therapeutic intervention, meaning transplantation will remain the main option for severely affected patients. This well-recognized need, along with the lack of donor organs will ensure bioprinted livers will continue to be well funded. But the value of the project goes beyond liver disease, as the new technologies developed in the frame of OrganTrans will not be limited to liver applications. They relate to the challenges of biofabrication of any organoid-based tissue, which can potentially be beneficial for a large variety of indications.

Can you tell me more about the role of regenHU within the OrganTrans consortium?

Such a complex and ambitious endeavor needs very different and complementary knowledge and competences. Teamwork will be a central element, first to enable, then to accelerate, these new solutions. With this in mind, we have been reorganizing regenHU to bring better project collaborative capabilities to this project, and others like it that we are engaged in. regenHU is a pioneer and global leader in tissue and organ printing technologies converging digital manufacturing, biomaterials, and biotechnology to lead transformational innovations in healthcare. We focus on delivering advancements in the instruments and software required for tissue engineering, and our technology evolving along with the biological research of our partners. We, therefore, consider these partnerships with the scientific community critical for our development.

An outline of the OrganTrans project (Image courtesy of OrganTrans)

regenHU is one of the largest contributors to this project, is this part of the company’s commitment to regenerative medicine?

We can see the need for biotechnology solutions for a wide range of disease states. Our strengths are in engineering the instruments and software necessary to allow the producers of biomaterials and the suppliers of cells to combine their products to achieve functional tissues and organs. Our commitment is to provide disruptive technologies that will enable the community to make regenerative medicine a reality, with precision and reproducibility in mind, for today’s researchers and tomorrow’s industrial biofabrication needs. One of the key challenges is the current limitation in the scale and volume of bioprinting which is linked to the reproducibility of the print. To progress into the manufacture of medical products, bioprinters will need to operate at a scale beyond current capabilities. We design our instruments with these goals in mind and have assembled a team to solve the many challenges to achieve this.

How advanced is the bioprinting community in Europe?

The 3D bioprinting field is several years behind mainstream 3D printing, with the industrialization of the instruments, biomaterials, and cells required before bioprinting can progress to commercial-scale biofabrication. However, as with continued development seen in 3D printing, the technology convergence required for tissue and organ printing that changes medical treatments will become a reality through the efforts of engineering companies like regenHU, biomaterial developers, and human cell expansion technologies, being combined in projects such as OrganTrans.

As the newly appointed CEO of the company, how do you feel taking on this project?

Successfully entering the OrganTrans consortium is just one part of the company. regenHU investors see my arrival as the catalyst to bring regenHU to the next stage in its evolution. Our goal remains the production of industrial biofabrication instruments capable of delivering the medical potential of bioprinting, novel bioinks, and stem cells. To achieve this, we are enhancing the team and structure of the company, bringing forward the development of new technologies and increasing our global footprint to better support our collaborative partners. I have spent many years in regenerative medicine and pharma and can see the potential of bioprinting to revolutionize many areas of medical science, so joining regenHU was an easy choice. As CEO, my main role is to provide the right support structure to enable our entrepreneurial engineering teams to thrive and be brave enough to push boundaries. Additionally, as we cannot achieve our end goal on our own, I am here to nurture the important connections with our user community. Only by listening to their valuable insights and solving problems with them, we will push the technology onward.

The post regenHU CEO: Bioprinting Will Strengthen OrganTrans Project to 3D Print Liver Organoid appeared first on 3DPrint.com | The Voice of 3D Printing / Additive Manufacturing.

Polish Company CD3D Opens Largest 3D Bioprinting Cluster in Europe

Centrum Druku 3D, or CD3D, is the largest online website devoted to 3D printing technology in Poland. Launched in 2013 with an online portal, the company’s operations are based on two important pillars: providing knowledge in the 3D printing field, and scientific-research and R&D activities in the medical and pharmaceutical sciences. In 2014, CD3D held Poland’s first 3D printing awards, and this week launched a new medical project – the largest 3D bioprinting center in Europe.

The Open 3D Bioprinting Cluster launched in Lodz at the Bionanopark, which is one of the country’s largest laboratory complexes and works on multiple science and research projects in the medicine and biotechnology fields, including computational chemistry, 3D printing, biochemistry, and medical implants. CD3D, under the CD3D Medical brand, is the creator of the cluster, and will be operating it together with the Laboratory of Molecular and Nanostructured Biophysics at the complex, which also includes an incubator and conference center. In addition to bioprinting, CD3D Medical also offers SLA, FDM, and DMP 3D printing technologies.

21 3D bioprinters, created by CD3D and called SKAFFOSYS for ‘scaffold systems’, make up the cluster, and according to Pawel Slusarczyk, a Project Director at CD3D, they are the first Polish bioprinters.

The system uses a 5 ml syringe as a printhead, and performs extrusion mechanically, as semi-liquid, gel, and hydrogel materials are applied to a laboratory pan that’s been affixed to a working table. The SKAFFOSYS Lite 3D bioprinter features a 170 x 125 x 80 mm build area, with a process accuracy of 0.2 mm, and can also complete bioplotting. As more challenges are created over time by bioprinting projects, CD3D will expand the SKAFFOSYS Lite by adding new functionalities and modules.

Due to the teamwork between the Bionanopark and CD3D Medical, scientists are able to use additive bioprinting to complete comprehensive research and development projects in the biomedical engineering field. Under the close supervision of CD3D specialists and scientists from the Laboratory of Molecular and Nanostructured Biophysics, laboratories at the Bionanopark can now successfully complete, according to the website, “biochemical, biological and molecular research at virtually any stage of the creation of three-dimensional structures.”

The reason the 3D Bioprinting Cluster is so important is due to its open nature. We use 3D bioprinted structures for a myriad of purposes, from growing biological material on printed scaffolds and creating composite materials to researching alternative food sources and creating, studying, and testing out new types of biocompatible materials. So the fact that this large, new cluster for 3D bioprinting is open means that other external entities can use its important resources to complete tasks such as commissioning a comprehensive scientific and research service.

The partners and customers of the new Open 3D Bioprinting Cluster in Poland can now rest assured that the comprehensive service will make it possible to outsource scientific research projects to all of the laboratories in the Bionanopark.

What do you think? Discuss this story and other 3D printing topics at 3DPrintBoard.com or share your thoughts in the Facebook comments below.

[Images: CD3D]

Printing Lungs Using 3D, Bioprinting, and Stem Cells

via MIT Technology Review

Last month I had the chance to hold a replica of the upper part of a human airway—the windpipe plus the first two bronchi. It had been made from collagen, the biological cement that holds our bodies together. It was slippery and hollow, with the consistency of undercooked pasta.

The structure had emerged from a refrigerator-size 3-D printer in Manchester, New Hampshire, at an outpost of United Therapeutics, a company that earns more than a billion dollars a year selling drugs to treat lung ailments.

One day, the company says, it plans to use a printer like this one to manufacture human lungs in “unlimited quantities” and overcome the severe shortage of donor organs.

Bioprinting tissue isn’t a new idea. 3-D printers can make human skin, even retinas. Yet the method, so far, has been limited to tissues that are very small or very thin and lack blood vessels.

United instead is developing a printer that it believes will be able, within a few years, to manufacture a solid, rubbery outline of a lung in exquisite detail, including all 23 descending branches of the airway, the gas-exchanging alveoli, and a delicate network of capillaries.

A lung made from collagen won’t help anyone: it’s to a real lung what a rubber chicken is to an actual hen. So United is also developing ways to impregnate the matrix with human cells so they’ll attach and burrow into it, bringing it alive.

“We are trying to build the little stick houses for cells to live in,” says Derek Morris, a project leader in United’s organ manufacturing group.

Read more!