3DEXPERIENCE: A Virtual Journey, Part 1

Due to the ongoing COVID-19 crisis, this year’s 3DEXPERIENCE Forum by Dassault Systèmes had to be re-imagined as a virtual event, just like so many other conferences. At 1 pm EDT on July 29th, nearly two months after the in-person event was meant to have taken place in Florida, the company began the live stream of the Plenary Session for “3DEXPERIENCE: A Virtual Journey,” a series of digital programming that replaced the annual North America customer event.

Unfortunately, the webinar seemed to be having issues, which continued on and off over the next two hours of the live stream, so I missed pieces here and there. Technical difficulties happen all the time at live events, too, so the only real difference here was that I couldn’t raise my hand and say, “I’m sorry, the audio and picture cut out, could you repeat that please?” Luckily, Dassault had the webinar up to view on-demand the very next day, so I was able to go back and check out the parts that I had missed.

Erik Swedberg, Managing Director, North America, Dassault Systèmes, got things started with his segment on “Business in the Age of Experience: Challenges and Opportunities for North America,” which focused on manufacturing and supply chains, and why companies looking to transform, some sooner than they’d hoped due to the pandemic, should “invent the industry of tomorrow,” rather than trying to digitize the past or the present.

“Yesterday, businesses focused on automation of the manufacturing system; this is Industry 4.0. Today, many industrials are digitizing the enterprise system. It’s not enough. You need to create experiences. Tomorrow, the game changers will be those with the best developed knowledge and know-how assets. Why? Simple. Because the Industry Renaissance is about new categories of new industrials creating new categories of solutions for new categories of consumers,” Swedberg said.

He mentioned Tesla and Amazon, companies in Silicon Valley working to create autonomous vehicles, and fab labs creating and printing smart, connected objects.

“The 3DEXPERIENCE platform is a platform for knowledge and know-how—a game changer, collaborative environment that empowers businesses and people to innovate in an entirely new way,” he continued. “Digital experience platforms for industry, urban development, and healthcare will become the infrastructure for the 21st century.”

Swedberg explained how 3DEXPERIENCE can allow any business to become social, by connecting employee innovation into the system where the company’s products are designed. This was a common theme today, which you’ll be able to see later.

He also explained that, with Dassault’s 13 brand applications—such as SIMULIA, CATIA, and SOLIDWORKS—the company can serve a wide variety of industries, helping its customers on their journey to invent tomorrow’s industry.

“In summation, we are in the experience economy, the Industry Renaissance is here, and world events are accelerating the need for digital transformation. As the world changes, we will partner with you for success,” Swedberg concluded. “We have the people and the insights to help you on your journey.”

Dassault’s Vice Chairman & CEO Bernard Charlès was up next, speaking about “From Things to Life.” He first said that he hoped no one on the live stream, or their loved ones and colleagues, had been impacted by the COVID-19 crisis.

“We’ve gone through a tough time, all of us. And we are with you, and we are learning a lot also from the crisis,” Charlès said.

Even though I’ve worked from home for nearly four years now, other aspects of my life have been turned upside down in the last few months, and I felt a kind of solidarity whenever the session’s speakers brought up how all of our lives, and our industry, have changed. Charlès also congratulated everyone signed into the live stream on working together, and continuing to innovate, during the pandemic; the continuing health crisis was another theme that threaded throughout the plenary session.

He said that the 3DEXPERIENCE platform is about inclusiveness, “because it means ideas and people connecting.” He shared some of the work that 3DEXPERIENCE users had accomplished during the recent and varied quarantines, such as creating respirators, improving logistics, and working to make the quality of airflow in hospitals better. He said that all of these projects were done on the 3DEXPERIENCE cloud.

“So many of you accelerated the cloud implementation, to be able to work from anywhere, especially from home, during confinement time.”

He mentioned that we are moving from a product economy to an experience economy, and that, in the long run, companies will continue to produce, and maintain ownership of, products and services throughout the life cycle, while their customers will get to enjoy the experience.

“That will accelerate innovation for a sustainable world,” Charlès said.

Next, he talked about a few companies that have been using the 3DEXPERIENCE platform for interesting projects, like California-based Canoo, which dreams about refining urban mobility with an electric vehicle that can be used as a service or subscription, rather than being owned by individuals.

In order to create innovation, Charlès said, you need to be sure that your digital platform will work, and Canoo stated that 3DEXPERIENCE hit the mark here, helping to speed things up in the product development process.

He then talked about Arup, a company that’s using the 3DEXPERIENCE platform to create a virtual Hong Kong for city planning purposes. Arup is working to make Hong Kong a smart city, and the platform is helping the company in this endeavor; for example, Arup and Dassault just completed a project called the Common Spatial Data Infrastructure Built Environment Application platform…say that three times fast.

Finally, Charlès explained that the role of life sciences is to “protect what we care about,” and said that industry pioneers are coming up with new and different ways to diagnose and care for people. He stated that creating new healthcare experiences is a complex project, because it means converting big data into smart data and simulating real world situations in a virtual world. Luckily, 3DEXPERIENCE can help with this.

“3DEXPERIENCE…is a system of operation, because the platform can help you run your business, and the platform should also help you invent a new business model,” Charlès concluded. “The common values across all the industries we serve is putting the human at the center of everything we do.”

Next, Renee Pasman, Director of Integrated Systems at Skunk Works for Lockheed Martin, provided an overview of using the digital thread, and the 3DEXPERIENCE platform, for the product lifecycle, “and how Lockheed Martin is leveraging it to drive increased affordability, efficiency and collaboration throughout the lifecycle.”

“…Our projects cover the entire product life cycle that you might imagine from an aerospace and defense type of program, all the way from conceptual design through modeling and simulation, manufacturing, to sustainment and end of life,” she explained. “And one key part of the Skunk Works culture in the last 75 years has been very close collaboration across all of those areas. What we’ve learned as we have started this digital thread initiative is that by giving our workforce these latest tools, we’ve been able to make that collaboration easier, to be able to make it go faster, to be able to bring data in sooner, make better decisions, see what the impacts are of those decisions, and use that to guide where we are going.”

She explained that the product lifecycle “really starts with design,” and said that by starting this new Near Term Digital Thread/Affordability initiative and giving its workforce the 3DEXPERIENCE tools, Skunk Works has learned that collaboration is faster and stronger, and that we “make better decisions to guide where we’re going.”

We’ve all heard about this issue before—there are two versions of an important product document, and some people update one, while others update the other, and no one has a clear idea of which version is correct and most up-to-date. It’s frustrating to say the least. But Pasman noted that by using the 3DEXPERIENCE product lifecycle management platform, “we’re starting to see efficiency benefits now.”

Pasman also said that the Skunk Works team has learned something “unexpected” with the platform, and that’s the social collaboration it provides, which allows users to “make changes with a level of certainty.”

“We hadn’t necessarily focused on this area, but our teams really used this environment to collaborate better, and found it to be very useful to have all information in that single source of truth.”

Pasman also noted the usefulness of having a life cycle digital twin, as it “allows us to tie it all the way back not just to manufacturing but actually back into design, and making sure the data flows in the digital twin seamlessly.”

“I think if you talk to maintainers or sustainment and users, there’s a lot of time spent putting data into different systems. By making it easier to do that, it allows people to focus on the hard parts of their job, and not just the data entry parts,” she explained. “Collaboration between different areas and getting data flowing is where we see a lot of the benefit from 3DEXPERIENCE, from affordability and product quality perspectives. We’re focused now on how to take the next step in this journey and improve schedule and affordability to fit into the market space that we are working in today. That’s where a lot of the work from our digital thread initiatives have been focused.”

Next up, Craig Maxwell, the Vice President and Chief Technology and Innovation Officer for Ohio-based motion and control technologies leader Parker Hannifin, spoke about “Simple By Design.” The multinational company has been integrating some of the tools that Dassault has been developing over the past few years, which has been valuable to the company.

“When we look at any enterprise or business, we saw these as opportunities that would manifest themselves as complexity,” he said in reference to the image below. “An average customer experience, which might be the ability to ship on time, with high and consistent quality. Of course, inconsistent delivery would manifest itself as complexity. High cost would be complexity…and then all of this would beget complexity in its many forms.”

GIPI = Global Industrial Performance Index

He said that all of these complexities can add up to new opportunities to take the company on the path to high performance. Maxwell also explained that the company’s traditional simplification efforts had revolved around design and organizational structure, explaining that 80% of any business’s profits and sales come from 20% of its portfolio.

“So by slicing and dicing that, could we eliminate complexity? The answer is a resounding yes,” Maxwell said.

He explained that 70% of a product’s cost is design, while 30% is labor and overhead, like lean manufacturing and the supply chain. The key is to spend less time on L&O, or conventional simplification, and work harder to reduce business complexity in that 70% design range. He said there are hundreds and thousands of decisions made on the L&O side, which, while easier to change, had a more limited impact on the long life cycles of their products.

“There were processes in place that we felt could address that reactively, not proactively,” he said.

With design, the decisions made were “relatively few and quick,” even though they could make a significant impact, because they would be difficult to change, mainly due to expensive tooling.

“We believe that if we can address design complexity, it would enable us to move faster and to grow by taking market share,” Maxwell said.

He explained that the cross-functional team Parker Hannifin set up to address “new” product complexity in a proactive way knew early on that there are two different value streams of Simple by Design.

“New products, for sure, but also core products,” he said. “If you look at where the money is, new products get a lot of attention, but our business is core products…they’re undergoing revisions constantly because our customers are asking for things that are different.”

The team decided to tackle new products first, and spent a lot of time working on design-related objectives, which is where they thought “a lot of the complexity and cost was being created.” He explained that the team wanted to keep the customer at the center of their attention, figure out what their pain points were and what they wanted, and get rid of the things that didn’t add value.

“The first principle of Simple by Design is design with Forward Thinking. With that deep customer engagement, anticipate what your customers are going to ask for in the future,” he explained. “Are there things we can do to the design of the product that, without increasing cost, that will allow us to make changes to it at a later date? The second principle is Design to Reduce, so to reduce complexity, can we reduce the number of new parts that we have, can we reduce the number of new suppliers we have? Can we eliminate proprietary materials that might be hard to come by?

“Design to Reuse – can we reuse parts that already exist? Why do we need to invent new when we’ve already got very similar or exactly what we need released into the system…and then finally, if we do the first three, we should see flow in the factory. We should not see the kind of bottlenecks that we experience today.”

Maxwell said that Dassault comes in with software tools that provide access to data, which “is the big game changer.” He talked about all of the many books and catalogs that were in his office at the beginning of his career, noting that engineers today just can look at all of this information online, because they have access to data. Parker Hannifin estimates that it has about 26 million active part numbers, which is a lot to keep track of, and Maxwell said that roughly 45% of a typical design engineer’s time is spent searching for information.

“So if I had access to the data behind that 26 million part numbers, what would happen? And today, I’m not embarrassed to say that generally we don’t. There’s a lot of things that we do many many times, we’re a very diversified company, we’re global, ” Maxwell said. “It’s not unusual for people to spend their entire career here in the company and not talk to a lot of other operating divisions…outside of the one they work in. So what if I could connect them and give them access to information, what kind of leverage might I enjoy?”

He brought up the company’s usage of Dassault’s EXALEAD OnePart, which can give multiple division access to this kind of information. Maxwell said that this software was used “early on in testing and in value creation,” which was very helpful in finding duplicate parts or component-level parts that already exist in the system, so no one had to create a new part.

Below is a test case he showed of Parker successfully using Dassault tools. FET is an industry-standard 6000 PSI thread to connect couplings, and there are a lot of competitors for parts like this. The company was working to design a new series that was more of a premium product than the original FET.

“We applied simplified design principles,” he explained. “There’s four different sizes, it was bespoke, very distinct from the FET series that was standard. It was fully validated and ready for launch. But it added 147 component parts to the value stream.”

The team focused here, and used the simplified design principles to make the decision to recycle the validated part, and go back to the drawing board.

“Is there an opportunity for us to reuse some of the parts that already exist in the FET series in the new 59 series, but still maintaining the 59 series’ premium features and benefits?”

You can see the results of keeping things simplified above—123 parts were eliminated, while keeping the series at 100% function. The new 59 series shares 90% of its components with the original FET series, and no additional capital was spent on equipment. Costs and inventory went down, and delivery went up, which Maxwell called a “great example of flow.”

Swedberg then introduced Florence Verzelen, Executive Vice President, Industry, Marketing, Global Affairs and Workforce of the Future for Dassault Systèmes, who would discuss “How to Transform the New Normal into an Opportunity.”

She opened by discussing how the COVID-19 crisis has changed everything, such as having to stay home and social distancing, and I’m sure we all agreed with this statement. But now we’re entering a new phase of building back after the pandemic, and building back better, as businesses reopen.

“How do you think you managed during COVID?” she asked. “Are you ready to transform, to perform better in the new normal world? Do you know how to become more resilient and therefore be prepared for the next crisis?”

Verzelen discussed some of the stark numbers coming out of the pandemic, such as 53 million—the number of jobs considered to be “at risk” during confinement and quarantine.

“In the 21st century, we have never seen a crisis of this amplitude,” she said. “And when it happens, as industry leaders, there are really two things, two imperatives, we should consider. Ensure the survival of our company, and contribute to the safeguard of the economy.”

There are five actions to take here, and the first priority is to protect employees and make sure they can safely do their jobs.

Verzelen explained that the 3DEXPERIENCE tool SIMULIA can help with this in many ways, such as simulating the airflow in a building’s corridors. She also said that companies can “implore their employees to work from home” without disruption, which is possible thanks to Dassault’s cloud solution.

The second thing necessary to keep your company surviving is maintaining its financial health.

“COVID-19 has affected the liquidity of many companies,” she said. “Less revenue, more costs…and in order to make decisions, you need to be able to build a scenario.”

Online sales can help keep companies afloat during a crisis, and also help maintain the connection to customers. Dassault can help with these as well through its data analytics solutions and digital tools. Adapting your company’s marketing and sales for an online experience is the third way to ensure its survival.

The fourth thing is to safeguard the supply chain. The disruption of one supplier can decimate production all the way down the whole chain, which can include suppliers in locations all over the world.

“During a crisis, it becomes essential to know where the weak points are,” Verzelen said. “This again we can do thanks to digitalization and thanks to data analytics.”

Finally, companies need to help the ecosystem, otherwise it will not survive. Dassault made sure that all of its solutions and tools were readily available on the cloud so that all customers could continue to work to keep the ecosystem going.

But, even though the world is slowly coming out of confinement, Verzelen warns that “it’s not over yet.” The use of automation will likely increase, and e-commerce is skyrocketing in Italy.

“It’s the beginning of a new phase. It’s the beginning of what we call the new normal.”

A lot of decisions need to be made when you’re restarting a business. Again, Dassault can help with this by building scenarios, so companies know the right steps to take, and in what order, to successfully reopen.

“We all have to change,” Verzelen said. “We’re developing new capabilities for employees, and making learning experiences available online to make sure your teams are ready. Returning to business probably means we need to rethink our supply chain, and we know that a contact-limited economy is here to stay. So you should push for e-commerce, and be prepared to work in contact-limited economy.”

She stated that the 3DEXPERIENCE allows companies to “unlock unlimited value,” and help us cope during this new normal.

“There are many ways to be resilient, and all of those ways are linked to innovation and sustainability.”

The paradigm has changed, and we need to be realistic going forward, and focus on sustainability in operations and business models, such as turning to additive manufacturing if your usual supplier can’t get you what you need in time.

“With the 3DEXPERIENCE platform you can create this kind of business model…create more efficiently, design more quickly,” she said.

“In a nutshell, we are going through very difficult times right now…But this crisis can also be seen as an opportunity to rethink what we do, and build back better.”

Finally, Swedberg introduced three additional Dassault panelists for the final discussion: Dr. Ales Alajbegovic, Vice President, SIMULIA Industry Process Success & Services; Garth Coleman, Vice President, ENOVIA Advocacy Marketing; and Eric Green, DELMIA’s Brand Marketing Vice President. These three are in charge of the content for the rest of 3DEXPERIENCE: A Virtual Journey, as it continues on:

  • “Fueling Innovation for the New Agile Enterprise,” August 26th
  • “Modeling & Simulation, Additive Manufacturing,” September 23rd
  • “Enabling Business Continuity Using the Cloud,” October 14th

L-R: Swedberg, Green, Coleman, Alajbegovic

Green said that three themes would be articulated in these upcoming sessions, all of which will fall under the “sustainable operations” umbrella: data-driven decision-making, leveraging agile success and being agile for success, and business resiliency. Coleman mentioned that the many customer references and testimonials found on the 3DEXPERIENCE site provide many examples of how the platform has helped customers innovate across every industry…even wine-making! Dr. Alajbegovic said that they are “very excited” about the upcoming modeling and simulation sessions and additive manufacturing panels.

“In our sessions, we will look at ways to enable the marriage between modeling and simulation, thus revolutionizing design,” Dr. Alajbegovic said.

It’s not too late to register for 3DEXPERIENCE: A Virtual Journey, so sign up today to enjoy access to further digital programming from Dassault Systèmes.

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Dassault Systèmes: Revenue Report, New COO, Increase Focus on Virtual Twin

Dassault Systèmes, the 3DEXPERIENCE company, is starting the weekend with a little business, by making several announcements. First, the company revealed its IFRS unaudited financial results for the 4th quarter and year ended December 31st, 2019. The results, reviewed by the Board of Directors earlier this week, show that Dassault’s total revenue went up by 13%, from €3.65 to €4.06 billion, and that it’s expected to keep growing in 2020 by 21-23%. You can read the highlights, and financial summary, for Q4 and Fiscal Year 2019 here.

“All IFRS and non-IFRS figures are presented in compliance with IFRS 15 and IFRS 16, which have been applied since January 1st, 2018 and January 1st, 2019, respectively,” Dassault declared in a news release.

The company also announced that its Chief Financial Officer, Pascal Daloz, has now also been appointed Chief Operating Officer. In this new position, created to help expand Dassault’s strategic direction and empower its “new generation of leadership,” Daloz will lead the new Operations Executive Committee, which will support the company’s goal to drive innovation in the sectors of manufacturing, life sciences and healthcare, and infrastructure and cities.

“Pascal’s strong knowledge of Dassault Systèmes and his skills in a wide range of domains such as science and engineering are major assets that will enable him to accomplish the dual role of Chief Operating Officer and Chief Financial Officer.  His appointment also reflects our plan to prepare for the company’s future while maintaining continuity in its leadership and direction,” stated Bernard Charlès, the company’s Vice Chairman and CEO. “In only two years as CFO, Pascal has already defined new strategic and financial ambitions for the company. For these reasons, Pascal is the right person to help me implement Dassault Systèmes’ vision of transforming industries, markets and customer experiences with the 3DEXPERIENCE platform, ensure the execution of the company’s holistic, growth-centric strategy, and manage its performance.”

Daloz joined Dassault Systèmes in 2001 as Vice President Research & Development in charge of market development, and has been moving up the ranks ever since, including being named Executive Vice President, Brands and Corporate Development in 2014. He has helped the company enter new sectors and embrace future trends, including acquiring Medidata in October; this decision helped to cement life sciences as Dassault’s second largest core industry. As COO, he will coordinate the company’s operational decision-making processes for strategic functions, including the 3DEXPERIENCE platform and its 11 brands.

Speaking of life sciences, the company has announced its strategic direction for the future, which focuses on solutions for the life science industry through developing the human digital twin – really, a virtual twin.

“In 1989, we created the first virtual twin of a giant airplane, the Boeing 777,” explained Charles. “In 2012, observing that the world was shifting to an experience economy that values usage over product, we dared to imagine a platform that would use comprehensive virtual twins of things as the place to navigate, evaluate, and holistically experiment with an idea to make it reality. We named it the 3DEXPERIENCE platform. Our customers, as they adopt it, are making it the catalyst and enabler of the Industry Renaissance. Our ambition to harmonize product, nature and life remains the same, while its scope is broadening. It has led us to develop a new understanding of life and nature.  Today, we’re capable of applying the knowledge and know-how we acquired in the non-organic world to the living world, extending our focus from things to life. The virtual twin experience of the human body will enable us to invent new ways of representing life by understanding and representing the invisible, and make a lasting contribution for the benefit of all.”

You’ve likely heard of the digital twin, which is an idea that in the digital manufacturing world, by combining software with mass customization, every product in a company’s inventory will have a unique file that contains all of its specific settings and production information. But the human body is far more complex, and the healthcare industry needs to refine how therapies for patient care are discovered, developed, produced, used, and commercialized. A virtual twin can change how we cure people, as it enables health-related disciplines to understand, test, model, and treat the human body – just like the digital twin makes this possible for products in industrial sectors.

“Why “virtual” rather than digital? Well, precisely because the value of what we do lies in the potential it offers for imagining the future. “Virtual” is about what’s possible – the potentiality. In that sense, the virtual is the very essence of human nature: we are virtual beings. We are beings of possibility,” Dassault writes on its website.

“So to improve life, we have to invent new ways of representing reality. We have to invent the virtual twin experience of life.”

The 3DEXPERIENCE platform can integrate collaboration, information intelligence, modeling, and simulation to make a virtual twin of the human body possible. By combining material sciences, information sciences, and biosciences, stakeholders will be able to to actually project an object’s data onto a living, virtual model, which can then be configured and simulated for research and testing purposes. For example, before a human patient is treated, researchers could potentially be able to see how a certain drug could affect a disease.

Dassault will be building up its leadership in healthcare and life sciences, along with manufacturing industries and infrastructure and cities, as these all have similar sustainability needs and development processes in the ongoing efforts to improve our overall quality of life.

Discuss this news and other 3D printing topics at 3DPrintBoard.com or share your thoughts below.

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AnelleO: 3D Printing to Create Devices for HIV Prevention, Birth Control and Infertility

Women and girls are disproportionately affected by the HIV/AIDS epidemic, comprising more than half of the estimated 37.9 million people living with the disease. Moreover, according to United Nations AIDS, some regions of the world, like sub-Saharan Africa, have an even higher burden, with women and girls constituting over 57% of the affected population, compared to 52% worldwide. With an unwavering increase of the disease along with antiretroviral treatments that can only help control the virus, not kill it, preventing HIV infection is essential. Researchers have been investigating for many years the use of intravaginal rings (IVRs) as devices for the delivery of agents to protect against the sexual transmission of HIV and other diseases, as well as to prevent unwanted pregnancies. At the University of North Carolina (UNC) at Chapel Hill’s Eshelman School of Pharmacy, professor Rahima Benhabbour has been passionately developing innovative technologies to improve health conditions for women. Using 3D printing technology and her startup company AnelleO, she is quickly creating a breakthrough IVR that will be more efficient in drug delivery and can be customized to women’s needs.

Benhabbour recently said that watching the CEO and founder of Carbon, Joseph DeSimone, demonstrating how his 3D printer worked during a TED talk, made her wonder how she could apply the technology to IVRs. Soon after, she established her own company to print intricate features on customizable devices that could help women worldwide.

“I’m from North Africa. I’m a woman. The thought of helping women–some that don’t have a way of protecting themselves or controlling their lives–that’s my ultimate passion. It’s a dream for me to give back,” said Benhabbour, also an assistant professor at the UNC/NC State Joint Department of Biomedical Engineering.

Benhabbour has been featured on Innovate Carolina (a team working closely with a network of university partners to turn novel ideas into economic and social value), for her use of 3D printing technology to prevent HIV infections and other health conditions in women. Since launching her AnelleO in 2016, Behnhabbour has been working on the first product, AnelleO PRO, a once-a-month progesterone-releasing ring for infertility and assisted reproductive technology. The ultimate goal of AnelleO is to create a more efficient drug delivery that can be customized to women and their individual needs since current technology for intervaginal rings is a one-size-fits-all product.

AnelleO PRO, the first intravaginal ring for infertility, aims to develop and test biocompatible 3D printed IVRs for the mechanical and release properties of a model drug called β-estradiol, then translate these methods to the target drug, progesterone. Benhabbour is using a novel 3D printing platform, driven by the proprietary Continuous liquid interface production or CLIP process, pioneered by Carbon. She also applies CAD software for specifying shapes and geometry, which is recreated via a photopolymerization process. AnelleO PRO IVRs are fabricated with CLIP using a biocompatible resin and takes just 15 minutes to print each ring.

According to Innovate Carolina, current products approved for progesterone supplementation are limited to messy and unpleasant vaginal gels or inserts and painful intramuscular injections that have to be administered daily. While AnelleO PRO could safely and steadily release progesterone over an extended duration, with the potential to replace current therapies and impact millions of women.

“Unlike traditional technology, 3D printing gives us the ability and engineering to play around with the design and properties of a product. We can engineer parts that would not have been possible before,” she suggested back in September. “The main goal of developing this 3D technology is to have the ability to change the ways in which women’s products are manufactured and designed. And the applications for the technology are endless – including prevention of HIV, sexually transmitted infections and unintended pregnancies.”

On a similar note, the National Institutes of Health (NIH) reported last July that another research open-label study of women in southern and eastern Africa, using a vaginal ring that is inserted once a month and slowly releases an antiviral drug, was estimated to reduce the risk of HIV by 39%. IVRs are quickly gaining prominence. However, Benhabbour’s idea to use 3D printing to develop them could be even more innovative than all the others, especially considering that the technology helps to cut down costs, print on-site, and would just require technical expertise to run the machines. This means that in regions where it would take longer to receive the IVRs–due to logistics or high costs–specialists could actually print them within minutes for patients. In the end, it all translates to saving lives, reducing risks, and improving existing health conditions for women and girls.

Rahima Benhabbour at the lab

Originally, the Chapel Hill UNC spin-off company received the KickStart Venture Services Commercialization Award, which is part of Innovate Carolina’s campus-wide effort to translate discoveries made in Carolina’s academic laboratories into products and services that can benefit people both in the local vicinity and around the world.

Benhabbour suggested that “KickStart Venture Services gave us a ‘kickstart.’ You may have an idea, but no funding and KickStart helps make connections and gets things moving, while serving as an ongoing resource. The main hurdle has been to find business leads. KickStart helps faculty launch and carry their startups, because we’re too busy in our academic lives to be the lead of a company. We need that support with the business know-how. That support has been tremendous.”

A critical source of funding came from the Eshelman Institute for Innovation (EII) at the Eshelman School of Pharmacy. In this case, EII provided a $200,000 grant titled “Fabrication of Geometrically Complex Intravaginal Rings by Continuous Liquid Interface Production (CLIP) 3D Printing Technology” that helped Benhabbour initially create the technology. Such financial backing, along with the additional entrepreneurial support from EII, in partnership with KickStart and the broader Innovate Carolina team, bolstered Benhabbour’s early efforts to bring her concept to life.

The bioscience company, headquartered in North Carolina’s UNC at Chapel Hill, is quickly developing drug delivery technologies with uses in potential end markets including devices, reproductive systems, cancers, and other neoplasms. AnelleO also got a lot of help from the UNC Office of Technology Commercialization team (another part of the Innovate Carolina initiative) in helping with guidance on patents and licensing, not a minor issue when it comes to innovation. Her lab is packed with more than seven scientists, most of them women, something she is particularly proud of.

According to the expert, its not always easy for faculty members to pursue their big idea, yet she offers encouraging advice: “It’s hard for an academic, you always have questions. What I’ve learned is that if you have an idea, put it out there and talk to multiple people. Get it out there, and see what the potential is for your idea as opposed to looking at the hurdles. Instead of looking at how something won’t work, just think of what it can be.”

As a big part of her mission for innovation in science, Benhabbour has also been working on a seven-year research along with colleagues at Chapel Hill, to develop the first-ever injectable implant for HIV. The long-lasting treatment and prevention technology has been tested in animals and would make an enhanced injectable drug implant that is ultra-long-acting and can merge various drugs, while also dealing with a number of hurdles encountered with present HIV prevention and treatment techniques.

Benhabbour’s novel approach along with her ongoing interest and concern to help people with life sciences has led to innovative solutions that could stop life-threatening diseases and overall improve women’s lives. She moves away from traditional forms of drug administration, leading the way with her vision to incorporate the latest technologies to her up and coming lab efforts and new company. We expect to hear more about Benhabbour and her one-of-a-kind 3D printed IVRs.

Rahima Benhabbour and her team

[Images: Innovate Carolina, UNC at Chapel Hill]

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3D Printing News Briefs: August 18, 2018

In 3D Printing News Briefs, in which we share news about some upcoming events, and then move on to business, science, and 3D printing pen art. Europac 3D and Addition Design and Research are showing their plans for the upcoming TCT Show, and the Formlabs Roadshow is coming to Chicago next month. Makelab has launched its on-demand production platform, powered by AMFG software, and Rize published a brief about 3D printing in life sciences. Finally, 3Doodler announced an upcoming video class series on 3D printing pen art.

Europac 3D Announces Lineup for TCT Show 2018

Top UK 3D printing, scanning, and inspection business Europac 3D announced that its booth for this year’s TCT Show in Birmingham will be its “biggest and most informative” yet, showcasing the latest in 3D printing innovations. In addition to displaying and 3D printing a range of sunglasses during the show to illustrate its end-to-end solutions, the company will also display 3D printers from HP and UnionTech, NX software from Siemens, and 3D scanners from Artec and Kreon Technologies. Experts will also be on hand at Europac’s booth to answer any questions.

“We will have our biggest and best stand to date at TCT this year and will be hosting 3D printing, scanning and modelling experts to provide visitors with a one stop shop for all their technical queries,” said John Beckett, Managing Director of Europac. “Europac 3D will be on hand to demonstrate all of our latest projects and innovations. We look forward to welcoming visitors to our stand for what promises to be an unforgettable event.”

Check out what Europac to offer at Stand M26 at the TCT Show, running from September 25th-27th.

Addition Design and Research Attending TCT Show 2018

Another 3D printing company that’s announced its plans to exhibit at the TCT Show is contract research and development (CRD) supplier Addition Design & Research, which provides end-to-end advanced design and manufacturing solutions using 3D printing. While the company is rather new to the 3D printing industry, it’s long worked at the intersection of CRD, high value design and engineering, and AM with other organizations to create high quality business solutions.

Addition Design & Research will be available during the TCT Show at Stand K49 for one-on-one meetings to provide insight into its expertise, offer advice on how to adopt 3D printing, and to discuss collaboration. Any organizations in the UK searching for a primer on using 3D printing as a business solution should attend the company’s training course in Sheffield just ahead of the show.

Formlabs Roadshow Hits the Road in Chicago

The popular Formlabs Roadshow has visited many big cities, from New York City and San Francisco to Los Angeles and now Chicago.

“Formlabs is traveling to industry hubs across North America to celebrate the capabilities of 3D printing in digital manufacturing,” the event reads. “We are bringing together local innovators and global disruptors to discuss how accessible 3D printing technology is enabling manufacturing across the business and education landscapes. Join us as we tackle opportunities and barriers in digital manufacturing and design with industry experts.”

The event, which centers around taking advantage of Industry 4.0, will be held from 10:30 – 2 on Friday, September 14th at the Digital Manufacturing and Design Innovation Institute (DMDII). Speakers include several well-known 3D printing experts, including Luke Winston, the Chief Business Officer at Formlabs, and Siemens’ Additive Manufacturing Solutions Director Chris Weber, with more to be announced soon. Tickets are less than $70, so sign up here to attend.

Makelab Launched On-Demand Production Platform

Brooklyn-based 3D printing service bureau Makelab is partnering with AMFG, which creates automation software for industrial 3D printing, to launch a new on-demand production platform. AMFG’s software will automate Makelab’s manufacturing operations, as well as make its 3D printing services more accessible to universities, engineers, and designers. Customers can use AMFG’s on-demand portal to easily request 3D printed parts with its auto-quoting tool, while Makelab will be able to track parts and requests, automatically schedule jobs and optimize build space, plan for post-processing, and conduct quality assurance.

“With AMFG, we’ve found an end-to-end solution which not only takes care of the auto-quoting in a more user-friendly and intuitive way, but also takes care of managing production, which is a huge advantage for us. As we scale our business, we’re always looking for innovative ways to solve key issues like keeping track of all our machines, effectively packing builds and ultimately, optimising our workflow for maximum efficiency,” said Makelab Co-Founder Christina Perla. “AMFG answered all of these questions and more, so we can provide a faster, more efficient service for our customers.”

Rize Commissions Brief on Life Sciences 3D Printing

Boston-based 3D printing company Rize recently commissioned a new Insight Brief, titled “Personalized 3D Printing in Life Sciences,” written by Axendia’s Eric Luyer, an Industry Research Analyst, and Ellyn McMullin, a Research Associate. There are many applications for 3D printing in the healthcare, medical device, pharmaceutical, and surgery industries, and Life Sciences companies can use the technology to break down barriers. But there are plenty of complex regulations to be managed in order for this to be successful. The brief discusses 3D printing applications in Life Sciences, some of the FDA guidelines, and how Rize’s 3D printing Augmented Polymer Deposition (APD) technology is very important to controlling some of the important processes that Life Sciences manufacturers need.

“RIZE’S patented APD system is key to Traceability, Control of Process Parameters and validated processes that Manufacturers must maintain and control to meet FDA 21 CFR 820.30 Design Controls requirements. It’s an industrial 3D Printer where complex geometry can be manufactured matching patients’ anatomy,” said Kishore Boyalakuntla, Vice President of Product at RIZE.

The brief also discusses how global medical device manufacturer CONMED used Rize’s technology to 3D print molds for producing medical-grade elastomeric products.

3Doodler Working on 3D Pen Art Video Class Series

Popular Kickstarter-backed company 3Doodler is working with Bluprint, owned by NBCUniversal, on a series of 3D Pen Art video classes aimed at teaching makers and crafters how to create works of art with the 3Doodler Create+ 3D Pen. Its content, available for free online through Bluprint, Craftsy, and streaming apps like Roku, will be part of the new entity’s expanded subscription service, and Grace Du Prez, an internationally renowned 3D pen artist whose work we’ve covered before, will be the host of the show, which marks the first such broadcast agreement for 3Doodler.

Six episodes will run through the 2018 holiday season, and the first five are already up, covering projects like phone cases, terrariums, and lantern lights; you will need to sign up for a free Bluprint trial to watch. The sixth video class will be an episode of Doodle Wars, a new, family-friendly NBC competition series. Check out a teaser video for Doodle Wars below:

NEW SHOW TIME: Doodle Wars is here ! These artists are incredible and thanks to this show I’m now calling myself Bob Ross Jr. Shoutout to Bluprint NBC and the whole awesome Hudsun Media team that made it happen and our great judges Zoe Hong + Jon Chad. Catch the whole season over at mybluprint.com now!….#doodlewars #iamadoodlerwarrior #doodle #scribble #draw #art #doodling #competition #mybluprint

Gepostet von Paul Costabile am Mittwoch, 15. August 2018

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Inexpensive 3D Printed Membrane Feeder Aids in Malaria Studies

[Image: National Geographic]

According to the Centers for Disease Control, in 2016 roughly 445,000 people around the world died of malaria, a serious disease caused by a parasite that often infects a certain type of mosquito, which in turn feeds on humans. 91% of these deaths were estimated to have taken place in the WHO African region, and most of these deaths were of young children, who are among the most vulnerable in areas of high transmission as they have not developed an immunity to the disease yet.

Malaria is one of the world’s most severe public health problems, and a lot of work has gone into using 3D printing to help diagnose and even cure the disease.

A group of researchers from Imperial College London is studying how malaria is transmitted, which requires mosquito test subjects to be infected with Plasmodium gametocytes – the blood stage parasites that actually cause malaria. In a Standard Membrane Feeding Assay (SMFA) test, an artificial membrane feeding apparatus, which simulates the host’s skin and body temperature, is used to get the mosquitoes to eat reconstituted blood containing the gametocytes. These feeders warm infected blood using glass chambers or electric heating elements, both of which are hard to acquire and expensive to boot.

The team recently published a paper, titled “An inexpensive open source 3D-printed membrane feeder for human malaria transmission studies,” that presents their creation and testing of an inexpensive, 3D printed membrane feeder.

“Presented here is a simple two-piece water-jacketed membrane feeder designed to hold a volume of 500 µl,” the paper reads. “Using the files presented here, the feeder can be 3D-printed directly and inexpensively by stereolithography by any equipped lab or commercial 3D-printing provider. Alternatively, by using a CAD package the size of the feeder can be up- or downscaled to hold more or less volume respectively.”

a) The membrane feeder was designed in two parts, a top chamber that connects to a circulating water bath and a bottom chamber holding a water reservoir and the RBC/gametocyte/serum sample on the underside. b) Both pieces are glued together into a single, watertight unit.

The researchers created the two-part membrane feeder design using the free, open source CAD modeling program Art of Illusion, then had Shapeways 3D print the parts out USP VI medical-grade “Fine Detail Plastic” acrylic resin (VisiJet M3 Crystal). Then, they conducted three independent SMFAs, using the Plasmodium falciparum laboratory strain NF54, in order to compare the performance of their 3D printed membrane feeder to that of a commercial glass feeder.

Comparative P. falciparum SMFAs with a commercial glass feeder and 3D-printed feeder.

According to the study, “Exflagellation rates as well as oocyst counts indicate that there is no significant difference between the two, within the statistical power given by triplicate SMFAs used as standard by the research community.”

The researchers believe that by making the design files for their 3D printed membrane feeder open source, more laboratories will be able to perform these SMFAs, and can even customize the design if necessary.

“The 3D-printed feeder design enables researchers to inexpensively produce their own SMFA feeders as an alternative to expensive and fragile glass feeders that require specialist manufacturing,” the study concludes. “This new 3D-printed feeder can be used in a wide range of applications in addition to standard SMFAs, as it is not limited to the species used here. Application might include the assessment of vector competence for malaria, the epidemiological assessment of the infectious reservoir for malaria, clinical drug trials, and transmission-blocking studies.”

Co-authors of the paper include Kathrin Witmer, Ellie Sherrard-Smith, Ursula Straschil, Mark Tunnicliff, Jake Baum, and Michael Delves. The design files for the 3D printable membrane feeder can be found in the paper.

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Merck becomes latest customer of RIZE ONE 3D printer

Boston based 3D printer manufacturer RIZE has confirmed Global life science company Merck (NYSE:MRK) as its latest customer. According to Andy Kalambi, President and CEO of RIZE,”Our RIZE 3D printing platform, with its clean process, clean materials and completely safe user experience, makes it very suitable for the life sciences industry,” “As a result, we are delighted to […]