Former CEO of Organovo Urges Stockholders Against Merger with Tarveda

Gaining a competitive advantage is at the core of most businesses. That is why the financial world has a section dedicated exclusively to study the behind-the-scenes of mergers and acquisitions (M&A). Between 1893 and 1904, the first wave of M&As became commonly known as the “great merger movement” in the US business scene, particularly the manufacturing sector. We’ve come a long way since then, and the two words became quite consolidated among financial experts and economic gurus as they decisively found M&As as a way to increase market shares, eliminate the competition or increase business diversification. However, contrary to what most people think, and according to a Harvard Business Review report, the failure rate for M&As is between 70% and 90%. And a KPMG study particularly determined that 83% of merger deals did not boost shareholder returns. Meaning they are not the best choice for most companies. That could be the case with bioprinting pioneer Organovo.

Last January, the company, announced a merger with Tarveda Therapeutics, a privately-held clinical-stage biopharmaceutical firm. However, at the time, the founder and former Chief Executive Officer (CEO) of Organovo, Keith Murphy, spoke against joining forces with Tarveda as part of a strategic alternative in the development of its human liver tissue for transplant. And just this Monday, Murphy decided to issue a new letter to stockholders discouraging them to vote in favor of the proposed merger with Tarveda, alleging that the firm’s financial position is “dismal” as well as the company’s “lack of synergies” and “highly questionable future prospects,” further reinforcing why a merger would be a terrible outcome for Organovo stockholders.

Under the terms of the original deal, announced in the company’s annual report published on December of last year, Tarveda would merge with a wholly-owned subsidiary of Organovo in an all-stock transaction and upon completion of the merger, the merged company would operate under the name Tarveda Therapeutics and trade on the Nasdaq Stock Market under the ticker symbol TVDA. Without any mention of Organovo’s bioprinting technology, we were left to wonder at the time whether the company’s pioneer technology and research activities would cease to exist.

Just like in January, this new letter provides details of what Murphy considers is wrong with Tarveda, even describing it as a company that “possesses unattractive technology that needs a bailout, via a reverse merger, just to survive.”

Murphy’s insistence on stockholders to vote “against” the merger is quite valid since the actual merger is still subject to customary closing conditions, which means that the merger still requires the approval of stockholders. Last December, Organovo directives suspected that the merger would be completed sometime in late 2020, however, stockholders may be persuaded either way in this waiting game.

Although personally attached to the biotechnology firm, Murphy resolves to take this drastic measure in order to speak directly to stakeholders, describing, not only, Tarveda’s “weak financial position with unexciting technology and unattractive prospects”, but also recognizing that Organovo is today “in its own precarious position due to recent mismanagement.” Concluding that he firmly believes that “the transaction being irrationally championed by the Board runs completely counter to stockholders’ best interests.”

Researcher working at the Organovo lab (Image: Organovo)

Bioprinting startups are emerging, and researchers’ interest in technology worldwide is helping many firms compete to develop better machines or upgrade previously successful ones. Organovo was one of the big driving forces behind bioprinting technology in the 2000s. However, recently, other companies have proven to be more successful, while Organovo’s stock price has been depressed for the past five years, going from USD 5.04 on June 6, 2015, to USD 0.27 on March 25, 2020.

On this last point, Murphy argues in his letter that “Organovo’s stock has been a relatively safer harbor, trending with the NASDAQ overall. Considering Organovo has natural downside protection due to being valued near its book value, I believe that waiting—and not consummating a reckless merger—may be the best course until the current storm has passed [that is, the novel coronavirus that began in December 2019].” While suggesting that, in contrast, “Tarveda is a company in need of additional capital beyond Organovo’s current cash in order to fund clinical trials to a successful point.”

In April 2017 Murphy stepped down as CEO of Organovo to create a new company, Viscient Biosciences, to develop drugs using human 3D bioprinted tissues. Nonetheless, he remained close to Organovo as chairman of the board and company advisor, even proposing a merger at one point between Viscient and Organovo to unlock 3D bioprinting potential.

In fact, Murphy maintains in his letter that “my assessment is unaffected by the Board’s decision to not pursue a merger with Viscient Biosciences (“Viscient”). While I firmly believe that the Board failed to create value for stockholders when it rebuffed what could have been a very synergistic merger with Viscient, I am fully aligned with you and recognize that there are many other viable combination partners out there. However, Tarveda is by no means an attractive deal partner.”

A few other reasons Murphy found discouraging against the merger involve Tarveda’s loss of its longtime Chief Scientific Officer (CSO), who was also President of Research & Development, in 2019, which he considered “hardly the sign of a strong technology.” As well as Tarveda’s downward trajectory following a prior record of poor investments, and that the company was running out of money in late 2019, with no venture capital funds or public market investors apparently eager to invest.

Massachusetts-based company Tarveda has been focused on developing Pentarin, a precision oncology medicine that selectively accumulates anti-cancer payloads within solid tumors. The company claims that following the closing of the merger, they intend to continue to focus on advancing two clinical-stage oncology programs, PEN-866 and PEN-221, and on the further development of novel conjugates from its proprietary miniature drug conjugate platform.Moreover, at the closing of the merger, they estimated that the combined company will have approximately 35 million dollars of cash on hand that is expected to provide sufficient funding into the second half of 2021 to achieve key upcoming clinical data milestones on both clinical programs.

Nonetheless, towards the end of the letter, Murphy offers three other options that he considers superior to the Tarveda transaction:

  1. The Board can abandon the merger to re-focus on organic growth via bioprinting.
  2. The Board should reconstitute its membership so that if the Board does not see the value of Organovo’s bioprinting opportunity following an abandoned or defeated merger, they should step down.
  3. The Board can run an improved Strategic alternatives process and rather than combining with a company that is in retreat, running low on capital and can only scrape together several months of cash in connection to the merger, the Board could admit its mistake and aim to find a combination partner that has upward trending progress of any type or the ability to leverage the company’s world-class bioprinting technology.

As Murphy concludes his arguments, he urges stockholders to review the terms of the merger closely, considering that they are “built on hopes and speculation about products and developments that I believe the circumstances prove have not been able to interest investment funds and have already lost support from VC [venture capital] funds.” He also believes that the “Board has not earned the right to have stockholders trust its judgment or its recommendation with respect to this merger. The Board’s record of value destruction speaks for itself.”

Keith Murphy

Organovo’s 3D bioprinting technology platform was once leading studies of 3D printed liver tissue, which was determined to even be capable of surviving and functioning inside an animal test subject. However, beyond 2017, reporting on biotechnology research from Organovo was hard to come by, and the company began to slip under the radar. Immediately after Murphy stepped down as CEO, Organovo holdings stock fell 5.2%, and a year later it dropped more than 28% as investors began growing impatient with the company’s slow pace of growth for its technology platform and products, which continued to deplete cash reserves. The company faces an uncertain future, and this new letter sheds new light on a merger that might or might not happen. Either way, stockholders will have to make their decision. Murphy already has. If you wish to read the letter by Keith Murphy follow this link.

The post Former CEO of Organovo Urges Stockholders Against Merger with Tarveda appeared first on 3DPrint.com | The Voice of 3D Printing / Additive Manufacturing.

3D Printing News Briefs: February 16, 2019

We’ve got business, events, software, and materials news for you in today’s 3D Printing News Briefs. MELD has introduced a new operator training course, and Protolabs is launching a range of secondary services. AMUG announced the keynote speakers for its upcoming conference, while the call has gone out for submissions to the 2019 Altair Enlighten Award. This week at SOLIDWORKS WORLD 2019, Stratasys introduced AdvancedFDM software for GrabCAD Print. Finally, a gold partner at America Makes has created an Ultem 9085 materials database for FDM 3D printing, and 3D MicroPrint is using a powder rheometer to push the limits of additive manufacturing.

MELD Manufacturing Offers Training Program

MELD Manufacturing Corporation is launching a new operator training program to teach participants how to operate its award-winning technology, which uses an innovative no-melt process to additively manufacture, repair, coat, and join metals and metal matrix composites. The 4-day courses will provide both classroom instruction and hands-on machine training, and attendees will also review the history of MELD’s development.

“This program creates certified MELDers and delivers the capacity to integrate and innovate with MELD. Our customers have raved about the elegance of the MELD process and the ease of training. We’re excited to offer more of these opportunities,” said MELD’s CEO Nanci Hardwick.

The size of the classes, which will be held at MELD’s Virginia headquarters, will be limited so that each attendee can have the maximum amount of machine time in order to become certified, so you should register ASAP.

Protolabs Launches Secondary Services in Europe

Protolabs is a digital manufacturing source for custom prototypes and low-volume production parts and offers all sorts of traditional and additive manufacturing services. This week, the company announced that it was introducing detailed measurement and inspection reporting, which will be only the first part of its newly launched in-house Secondary Services across Europe. These services will provide support for the company’s On-Demand manufacturing requirements, and will also help in launching more value-add secondary operations, like assembly and surface treatment, in the future.

“Our customers really value our rapid manufacturing services for low-volume parts and prototypes, but they now want the benefit of On-Demand manufacturing for production parts, which have higher expectations for sampling, measurement and process documentation,” said Stephen Dyson, Protolabs’ Special Operations Manager. “The marked increase from customers across all industries wanting to take advantage of the speed and flexibility of On-Demand manufacturing brings with it a desire to simplify the supply chain. We are offering Secondary Services to reduce the number of process steps that the customer has to manage, saving time and resources.”

Protolabs will hold a webinar for designers and engineers on February 28th as part of its Secondary Services launch.

AMUG Announces Keynote Speakers

L-R: Brian McLean, Brad Keselowski, Todd Grimm

The Additive Manufacturing Users Group (AMUG) recently announced who the keynote speakers will be for its 2019 conference, which will be held in Chicago from March 31st to April 4th. The conference, which will have nearly 200 presentations, workshops and hands-on training sessions, is designed for both novice and experienced additive manufacturing users, and the three keynote speakers will address the use of additive manufacturing in a variety of different applications. Brian McLean, the director of rapid prototype for LAIKA, will take attendees on a visual journey of how 3D printing has helped to redefine stop-motion animation, while NASCAR driver Brad Keselowski, the owner and founder of Keselowski Advanced Manufacturing (KAM), will share how technology such as 3D printing can help companies win the race. Finally, Todd Grimm, the president of T. A. Grimm & Associates, is returning to the conference as a keynote speaker again.

“We are extremely excited about our 2019 AMUG Conference keynote speakers,” said Gary Rabinovitz, the AMUG chairman and chair of its program committee. “They will provide a snapshot of the most transformative ideas shaping the AM industry today.”

2019 Altair Enlighten Award Submissions

Michigan-based technology company Altair, together with the Center for Automotive Research (CAR), are now taking submissions from around the world for the 2019 Enlighten Award, which is the only award from the automotive industry for dedicated lightweighting. The award will be presented in the categories of Full Vehicle, Module, Enabling Technology and The Future of Lightweighting, and winners will be recognized during the CAR Management Briefing Seminars (MBS), along with getting the chance to ring the Nasdaq stock market opening bell in New York. Suppliers and manufacturers can learn more about the criteria and submit an entry for the awards here.

“We are pleased to continue our collaboration with Altair because of their global leadership in solutions that produce the optimal balance between weight, performance and cost. This award helps drive innovation in lightweighting, which is critical to the success of e-mobility solutions,” said Carla Bailo, the President and CEO of CAR. “We can’t wait to see the key contributions the 2019 nominations will bring in new approaches to automotive engineering and design, contributing to further reductions in weight, fuel consumption, and emissions.”

Stratasys Announces AdvancedFDM Software for GrabCAD

At this week’s SOLIDWORKS World 2019 in Dallas, Stratasys introduced a new feature for its GrabCAD Print software that will remove more complexity from the design-to-3D print process. Advanced FDM will use intuitive model interaction to deliver lightweight yet strong and purpose-built parts to ensure design intent, and is available now via download with GrabCAD Print from versions 1.24 on up. The software feature will help users avoid long, frustrating CAD to STL conversions, so they can work in high fidelity and ramp up parts production, and it also features CAD-native build controls, so no one needs to manually generate complex toolpaths. Advanced FDM can automatically control build attributes, as well as calculate 3D print toolpaths, in order to streamline the process.

“For design and manufacturing engineers, one of the most frustrating processes is ‘dumbing down’ a CAD file to STL format – only to require subsequent re-injection of design intent into the STL printing process. This software is engineered to do away with this complexity, letting designers reduce iterations and design cycles – getting to a high-quality, realistic prototype and final part faster than ever before,” said Mark Walker, Lead Software Product Manager at Stratasys.

America Makes Ultem 9085 FDM Properties in Database

America Makes has announced that its gold-level member, Rapid Prototype + Manufacturing LLC. (rp+m), has created and delivered a complete, qualified database of material properties for the FDM 3D printing of high-performance ULTEM 9085 thermoplastic resin. This comprehensive database, which features processing parameters and both mechanical physical properties, was released to America Makes, and the rest of its membership community, in order to ensure the widespread use of the Type I certified material for 3D printed interior aircraft components. The database is available to the community through the America Makes Digital Storefront.

“The qualification of the ULTEM 9085 material and the establishment of the material properties database by the rp+m-led team are huge steps forward for AM, particularly within the aerospace and defense industries. On behalf of all of us at America Makes, I want to commend rp+m and its team for enabling the broad dissemination of the collective knowledge of ULTEM 9085 for the innovation of future part design,” said Rob Gorham, the Executive Director of America Makes. “The ability to use AM to produce parts with repeatable characteristics and consistent quality for certifiable manufacturing is a key factor to the increased adoption of AM within the multi-billion dollar aircraft interior parts segment.”

3D MicroPrint Identifying Ultra-Fine 3D Printing Powders

Additive Manufacturing Powder Samples

Germany company 3D MicroPrint uses 3D printing to produce complex metal parts on the micro-scale with its Micro Laser Sintering (MLS) technology, and announced that it is using the FT4 Powder Rheometer from UK-based Freeman Technology, which has over 15 years of experience in powder characterization and flow, in order to push the technology to its limits by identifying ultra-fine metal powders that will process efficiently. The system can differentiate raw powder materials, less than five microns in size, with the kinds of superior flow characteristics that are needed to produce accurate components using 3D MicroPrint’s Micro Laser Sintering (MLS) technology.

“With MLS we are essentially pushing standard AM towards its performance limits. To achieve precise control at the micro scale we spread powders in layers just a few microns thick before selectively fusing areas of the powder bed with a highly focused laser beam. The ultra-fine powders required typically behave quite differently to powders of > 25µm particle size,” explained Joachim Goebner, the CEO at 3D MicroPrint. “We therefore rely on the FT4 Powder Rheometer to identify materials which will perform effectively with our machines, with specified process parameters. Before we had the instrument selecting a suitable powder was essentially a matter of trial and error, a far less efficient approach.”

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