Interview with Jose Manuel Baena of Regemat 3D and Breca Health Care

Jose Manuel Baena

Jose Manuel is a healthcare entrepreneur and CEO, bringing new technologies from lab to bed to improve people’s quality of life. He is working in more than 20 countries. He is the Founder and CEO of BRECA Health Care and REGEMAT 3D. He is looking to pioneer the revolution of 3D printing and bioprinting in healthcare. He was born in Valencia in October 1983. He studied engineering in Valencia, Spain, Braunschweig, Germany, and Oxford, UK, where he got his MSc in Motorsport engineering supported by the grant program of F1 world champion Fernando Alonso. He has also studied biomedical engineering in Buenos Aires, Argentina, and he just finished his PhD in Biomedicine in Biomedicine at the University of Granada, he is now a doctor.

What inspired you to do a lot within the healthcare industry?

While working at the F1 team, I decided to focus my career on the intersection between engineering and medical sciences. I could have worked on designing cars but medical devices were more motivational and challenging for me.

Ten years ago I started researching and designing custom made implants and thought that, 3D printing could be used for doing amazing customized implants. In 2010, I started working on the BRECA Health Care Business plan. The company was founded in early 2011, and at that time 3D printing was not that popular. Various people told me that  I was never going to bring it to the clinical world. We now have dozens of successful clinical cases around the world.

Back in 2011, a researcher from the University of Granada asked him to develop a system in which we could print cells rather than Titanium, to solve the problems of apoptosis and the differentiation I had been working in 2D cultures. At that time the number of available solutions were 0. This is how I got inside this amazing industry. Some years later I started REGEMAT 3D to bring to society the results of our development from 2011. Now after few years we have a presence in more than 25 countries.

Early in 2018 and thinking on his future research after the PhD, I decided to get involved in a research group with a clinical focus to bring new treatments to patients that is how I started at the PITI3D platform as a Scientific coordinator and also a main figure in the start up of the platform.

Regemat 3D BioScaffolder 2.1

What are interesting things to pay attention to within the healthcare sector for bioprinting? How does 3D Printing revolutionize your day to day work?

We believe that bioprinting is in a kind of hype period. Biological sciences can benefit a lot from these ranges of different technologies, but it is not true that we are going to be printing functional organs in the short term. You can say that to do an IPO and get funding but after some years when results don’t ́t come as expected, you are going to fall. I saw it many years ago with 3D printing in medical devices, then after that the curve of expectations decreases and a lot of detractors arise. Just when you show the results it is when the technology starts being used and find a place in the market.

Also it is important to make clear that what we print with a bioprinter is not a tissue; it is a matrix, a scaffold, with cells in 3D, that as we showed many years ago behave in a similar way to the cells in vivo, but still a procedure that needs to have a functional tissue to be implanted.

Mechanical stress after printing and other ingredients play an important role in the outcomes of the tissue. We think of bioprinting as an amazing range of technologies to achieve our aims as researchers that want to mimic living structures but there still are a lot of things to do to cover all tissues. That is why we in REGEMAT 3D offer not just a bioprinting system but a customized one for every specific application. In the short term we see a lot of opportunities in the combination of 3D printed custom made synthetic medical devices and bioprinted structures to regenerate an injury.

Breca Health Care

What are some projects that Regemat has been working on recently?

We have been working on a lab on a chip Kit for antitumoral treatments. This includes Cornea Regeneration. We are also testing a new biomaterial based on the skin of a butterfly as well.

What are some projects that BRECA HealthCare has been working on recently?

We have worked on surgical guides, prosthesis and implants for Maxillofacial, thoracic box, osteosarcoma, and knee-related projects.

Are there ways to fuse these two industries as it seems that the work you do must have interconnection in order for one to transition between both?

Thanks to our previous experience with Breca Health Care, we offer some advantages to our collaborators such as:

  • Benefiting from all the results and new components developed by our bioprinting community
  • We can customize the solution and the specifications for your research. This will make it unique.
  • Funding opportunities
  • Royalties for co-development
  • As implanting medical devices experts, we will help you to bring your results from lab to bed
  • Advertising in media
  • Discounts in the modifications and ad hoc projects
  • Discounts in the new versions and components
  • Pre-clinical and clinical projects in cooperation with PITI3D

PITI3D

What are some concerns you have over the healthcare industry as a whole in terms of innovation? What are some benefits that the industry has as well?

The regulatory sector is important. We are now trying different applications with this technology at a pre-clinical phase, but we need to work on what will happen once we can go through the clinical applications with real patients. The benefit of this situation is the fact that we are helping to develop the regulation and we are completely involved in this sandbox.

Lastly, what is the future of bioprinting? What fields of study will be crucial for its future development?

Our approach is to create a tissue is quite unique as we are always thinking on the clinical application and how custom made surgical implants can promote the formation of a living tissue and the regeneration of a defect. For the creation of a living tissue it is crucial the bioprinting process and the ingredients selected to achieve the objective to create a functional specific tissue the scaffold, the cells, the bioinks and the other ingredients to be printed that will promote the formation of the right tissue. But also the maturation procedure applied to the 3D cell laden constructs, that is even more important. If we think about bioprinting as a technology to recreate all the structure in the same form as shown in a living tissue, we are going to fail. We have to think on bioprinting as a way of creating cell laden 3D constructs as a precursor of a functional tissue. The maturation and tissue formation process, in vivo or bioreactors mimicking the implantation body, will be as important or even more than the bioprinting one. Considering the strategies of both parts will be crucial to obtain the desired functional knee cartilage tissue. They are pioneering both fields!

Nano Dimension Continues its Growth in the 3D Printing Industry

Israeli PCB print leader Nano Dimension showed off its DragonFly 2020 Pro 3D printer at a US event for the first time while attending RAPID + TCT in Texas last year. Not too long ago, I finally had the opportunity to see the machine for myself while attending this year’s RAPID in Detroit, Michigan.

The industrial PCB printer was the first thing I saw at the booth – it’s hard to miss, being much taller than its desktop predecessor. The system stands on the floor and offers a larger footprint, though it has the same 20 x 20 cm print area as the original DragonFly 2020, which officially ended its beta program in the summer of 2017. Tim Sheehan, the VP of Global Sales and Customer Care for Nano Dimension USA Inc., came over to greet me, and we sat down to chat.

Sheehan used the example of an electrical engineer looking to make a prototype board, noting that everything involved in the process – from finding a business to make the prototype, filling out and getting a purchase order approved, having the prototype made and getting it shipped to you – can cost thousands of dollars and take months to complete.

“That’s the standard process that people deal with today,” he said.

“Now, along comes someone who says, what if I could increase your productivity and reduce your cycle time…that’s giving you a return on investment that’s going to help.”

Then we walked over to the DragonFly 2020 Pro so I could get a closer look. Sheehan explained that a dielectric ink (DI) and a conductive ink are both cured at almost the same time within the system.

“It takes sophisticated software to calculate the algorithm to make sure that what you want to be a feature on that board…something as simple as a hole…it places the hole each time at the appropriate place.

“The board is being printed on a chuck, and that chuck is a heating element and a holding element, so it’s holding what’s being printed.”

The chuck moves back and forth, while the ink is being distributed exactly where it’s supposed to go. Nano Dimension uses a free SOLIDWORKS add-in which, according to its website, “creates a design environment optimized for 3D printing multi-material electronics.”

“So all of this can allow that electrical engineer not to take all that time – that two days for approval, a week to get all the signatures, three to five weeks for the board to show back up, ordering of components – all that time. You can now have a board printed overnight.”

Sheehan told me that, as an engineer, the first design you come up with is never the best. The DragonFly 2020 Pro really helps to speed up the design process, so if you need to make changes and iterations, you’re not wasting everyone’s time. He then showed me some examples of what the PCB printer is capable of, including a 12-layer PCB (below) that took a total of 20 hours to print.


“Time is only determined by the amount of silver we want to put down,” he explained.

“No one else in here can do this. The only way this is being done is the old-fashioned, traditional way, which is one layer at a time is created.”

He also showed me a PCB with an indentation on one end where a battery will sit, which also features a circuit that’s on multiple layers.

Next, Sheehan brought out a sample that demonstrates a helical conductive coil – created in 180 extremely fine turns – that’s embedded in the company’s dielectric ink; this shows Nano Dimension’s ability to create non-planar conductors, and embed them in a structure, in a single process. This can be used in applications such as charging cell phones or as a solenoid, which acts like a magnet when carrying electric current.

“Solenoids generally grab something locked…unlock the solenoid, door opens,” he explained.

“I have children, I’m not home, they come home from school, the door opens, the signal gets sent, I know they’re home. This is the whole IoT, right? Related to electronics.

“So how this all plays through for us is I’m helping you increase productivity.”

I asked Sheehan if anything new was happening with Nano Dimension that he could tell me about, and he said that the company had recently begun a European expansion, in addition to completing its partner development in North America.

“We’ve signed on national and global leaders in additive manufacturing.”

He listed some of these, including additive solutions and SOLIDWORKS software reseller Go Engineer, CATI, and Fisher Unitech, which is the largest Stratasys reseller in the world.

“So, what else is new for us? A lot of what we call application development sharing – we’re introducing how we can help people side mount components, how we can help people create three-dimensional applications, like the inductive coil,” Sheehan explained. “That’s just a few of the many different, what we call ‘feature applications,’ we’re introducing to help people stretch their minds around what else you can do with the DragonFly.”

Nano Dimension has been listening to its customers, and until this point, the company’s “addressable market” has been R&D with major research institutes. But now, the US Department of Defense is one of the top markets it’s addressing, after becoming a certified DoD vendor last June.

“They are the biggest single organization buying from us today,” Sheehan said, noting that Tier 1 suppliers are also purchasing DragonFly printers. “There are different Army, Navy, Air Force branches buying this system, doing things that we don’t even really know because it’s not for us to know…we’re probably not allowed to know.

“So that’s exciting because when you bring a product to market, you want to know who to address in the market, you want to make sure you go target that. But what’s important is we gather the information from them, and then come back and do the appropriate things for the future of the product. So that’s been successful for us.”

Before I left, Sheehan presented me with my very own 3D PCB, which now sits on my desk next to a myriad of other prints I’ve made or been given. I was excited to receive the PCB, not only because it’s a good physical reminder of what 3D printing is capable of, but also, as I said to Sheehan, who doesn’t like to be handed a little white box?

Stay tuned for more on 3DPrint.com’s trip to RAPID + TCT 2019, and take a look at more pictures from the Nano Dimension booth below:



Discuss this story and other 3D printing topics at 3DPrintBoard.com or share your thoughts below.

[Images: Sarah Saunders]

Fortnite Battle Hound Mask #3Dprinting #3Dthursday

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nestechs shared this project on Thingiverse!

Sorry, I thought i had this posted. This is the awesome 3d file that Jace1969 posted but I split it into 4 pieces. I printed this on my CR-10s and only had to use supports for piece 1. The other parts had some dripping on the inside I had to snip off but it was better than printing a bunch of supports. In the end, I did add foam on the inside so it would fit my head correctly. Helmet looks awesome!

See more!


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Every Thursday is #3dthursday here at Adafruit! The DIY 3D printing community has passion and dedication for making solid objects from digital models. Recently, we have noticed electronics projects integrated with 3D printed enclosures, brackets, and sculptures, so each Thursday we celebrate and highlight these bold pioneers!

Have you considered building a 3D project around an Arduino or other microcontroller? How about printing a bracket to mount your Raspberry Pi to the back of your HD monitor? And don’t forget the countless LED projects that are possible when you are modeling your projects in 3D!

PowderPuff Unicorn #3DThursday #3DPrinting

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Shared by ChaosCoreTech on Thingiverse:

(Created by Chelsey)-I wanted to design a cute unicorn that is fun to print, so here it is! I designed it in Zbrush, and should be able to print without supports. If you scale it up quite a bit I would maybe add some supports to the tail area.

This unicorn was inspired by the filament color I had the chance to create while at ProtoPasta (PowderPuff Unicorn)

Download the files and learn more


649-1
Every Thursday is #3dthursday here at Adafruit! The DIY 3D printing community has passion and dedication for making solid objects from digital models. Recently, we have noticed electronics projects integrated with 3D printed enclosures, brackets, and sculptures, so each Thursday we celebrate and highlight these bold pioneers!

Have you considered building a 3D project around an Arduino or other microcontroller? How about printing a bracket to mount your Raspberry Pi to the back of your HD monitor? And don’t forget the countless LED projects that are possible when you are modeling your projects in 3D!

MX Fidget Cube #3DPrinting #3DThursday

E905c144c09aa52d1697bb416fbdaf2b preview featured

judy2k shared this project on Thingiverse!

A fidget cube, with spaces to insert 6 Cherry MX compatible switches and keycaps, resulting in a very addictive fidget toy.

This isn’t really a remix, it’s a redesign from scratch, although the basic structure is so similar to the original that it would be unfair not to credit the original design. It’s basically the same structure, but simplified and reinforced to make printing simpler. The original resulted in a messy print; this one is mostly a clean print on my Prusa MK3S.

See more!


649-1
Every Thursday is #3dthursday here at Adafruit! The DIY 3D printing community has passion and dedication for making solid objects from digital models. Recently, we have noticed electronics projects integrated with 3D printed enclosures, brackets, and sculptures, so each Thursday we celebrate and highlight these bold pioneers!

Have you considered building a 3D project around an Arduino or other microcontroller? How about printing a bracket to mount your Raspberry Pi to the back of your HD monitor? And don’t forget the countless LED projects that are possible when you are modeling your projects in 3D!

Floating Cup (easier to assemble) #3DThursday #3DPrinting

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Shared by bwaslo on Thingiverse:

This is a remix of HappyMoon’s “Floating Cup Sculpture” which I imagine about everyone has seen before. I didn’t want to try to print the spilling liquid of the “full water” STL using supports that would mess up the surface appearance of the spilling liquid. And I wasn’t able to cleanly assemble the three separate pieces that were given as alternate STLs by HappyMoon as I couldn’t easily position the pieces to hold them in place while glue set nor position them precisely enough to use an instant-hold type glue. My first attempt to assemble the three parts turned out to be a mess, and I ended up just welding the “Inside Mug” part to the “Stream” part with a soldering gun and that didn’t look very good.

So this remix takes HappyMoon’s :”full water” file and re-cuts the “splash” part from the “stream” + the “Inner Mug” parts, with places to insert alignment pins for precision and to hold the “water” together while adhesive sets. There is also an STL for the pins to use (two of them needed). I used 2-part slow-set epoxy to hold it together

Download the files and learn more


649-1
Every Thursday is #3dthursday here at Adafruit! The DIY 3D printing community has passion and dedication for making solid objects from digital models. Recently, we have noticed electronics projects integrated with 3D printed enclosures, brackets, and sculptures, so each Thursday we celebrate and highlight these bold pioneers!

Have you considered building a 3D project around an Arduino or other microcontroller? How about printing a bracket to mount your Raspberry Pi to the back of your HD monitor? And don’t forget the countless LED projects that are possible when you are modeling your projects in 3D!

U.S. Navy expands its metal 3D printing capabilities

The Naval Surface Warfare Center Panama City Division (NSWC PCD) in Florida has acquired a new metal 3D printer for its Additive Manufacturing Laboratory (AML). The addition of a EOS M290 3D printer will allow NSWC PCD to quickly produce parts and prototypes to ‘ensure warfighting dominance.’ “There are many advantages to having access to […]

Carbon, University of Wisconsin and Met-L-Flo win AMUG Technical Competition

The Additive Manufacturing Users Group (AMUG) has named its Technical Competition winners for 2019. Created in 2014, this competition provides entrants with a forum to showcase unique 3D printing applications and finishing capabilities. It is judged by a panel of five AMUG DINOs (Distinguished Innovator Operators) and has been announced in an exhibition at the AMUG […]

The Flare Gun #3DPrinting #3DThursday

1b4efb535a2740e8e8a8416a87645d40 preview featured

blondei shared this project on Thingiverse!

100% critical hit vs burning players

The weapon will reload when not active

  • Scaled to suit the size of the average hand size
  • Ripped from the original .vmf file and organized into individual pieces to make sanding and painting more convenient.
  • Doesn’t currently feature functioning moving parts :/

See more!


649-1
Every Thursday is #3dthursday here at Adafruit! The DIY 3D printing community has passion and dedication for making solid objects from digital models. Recently, we have noticed electronics projects integrated with 3D printed enclosures, brackets, and sculptures, so each Thursday we celebrate and highlight these bold pioneers!

Have you considered building a 3D project around an Arduino or other microcontroller? How about printing a bracket to mount your Raspberry Pi to the back of your HD monitor? And don’t forget the countless LED projects that are possible when you are modeling your projects in 3D!

Daedric Battleaxe split for smaller printers #3DPrinting #3DThursday

DingoF shares:

This is a model I split and sized for myself and decided post the files for it. It is split for my Anet A8’s printing bed (220mm x 220mm x 240mm). I scaled my model down to 95% because I thought it would be too big, but it ended up being a little too small, so it is the perfect size for a real life replica. All credit goes to Jace for uploading the original file, and to Bethesda for making Skyrim which this comes from. Shouldn’t need any supports

I included the blender files I used to scale and split the model just in case

download the files on: https://www.thingiverse.com/thing:3617314


649-1
Every Thursday is #3dthursday here at Adafruit! The DIY 3D printing community has passion and dedication for making solid objects from digital models. Recently, we have noticed electronics projects integrated with 3D printed enclosures, brackets, and sculptures, so each Thursday we celebrate and highlight these bold pioneers!

Have you considered building a 3D project around an Arduino or other microcontroller? How about printing a bracket to mount your Raspberry Pi to the back of your HD monitor? And don’t forget the countless LED projects that are possible when you are modeling your projects in 3D!